ORGANOCHLORINE

Organochlorine (Chlorinated hydrocarbons)

1)examples of pesticides in this class:
aldrin, benzene hexachloride, carbon tetrachloride, chlordane, chloroform, chloroneb, chloropicrin, 4-CPA, D-D, DBCP, DDD, DDE, DDT, dicamba, dicofol, dieldrin, endosulfan, fenac, heptachlor, hexachlorobenzene, hexachlorophene, lindane, methoxychlor, mirex, paradichlorobenzene, PCB, PCNB, pentachlorophenol, tetrachloroethylene, toxaphene, triclopyr

2)mode of action: Interferes with transmissions of nerve impulses across axons disrupting primarily the central nervous system.

3)immediate effects: Convulsions (may occur for several days after exposure); uncoordination; induces rapid metabolism of drugs and naturally occurring steroid hormones; hypersensitivity of skin or face and extremities; headache; dizziness; nausea; vomiting; tremors; confusion; muscle weakness; involuntary eye movements; slurred speech; pain in chest and joints; skin rash; labored breathing; central nervous system stimulation followed by depression; diarrhea; brain wave disturbances; hyperthermia; hypertension; salivation; sweating.

4)long-term effects: Cumulative; transfers through placenta to fetus; found in mother's milk; carcinogens; suspect teratogens; suspect mutagens; fetotoxins; aplastic anemia; "reproductive effects"; testicular damage; eye damage; affects hormone levels; central nervous system damage; bladder, kidney, liver, lung and thyroid damage; blood and spleen damage; anemia; recurrent asthma; irregular hearbeat; atrophy of adrenal cortex; behavior changes in young of mother exposed at even low levels during pregnancy; embryotoxin; decreased fertility; immunotoxin; abnormal brain waves; increased mortality in young; teratogens; porphyria cutanea tarda; sleep disturbance; hallucinations.

5)environmental effects: Bioaccumulate; persistent; many are volatile, traveling long distances in the atmosphere and settling in distant locations; decreased fertility in birds; egg-shell thinning in birds; groundwater contaminants.